It is possible for one person to take all five of them at the same time but note that they will only follow who spoke to them first.
Planted along the way are several NPC Giant Orobon's that roam erratically across set parts of the land. They have a fairly large agro range and will cause any Qiqirn Diver they see and 'aggro' to say "Aaahhh! Dooon't eeet meeee!" and run in a random direction.
The Giant Orobons are sight aggro and, every now and again, will occasionally stop for a moment. It is possible to run behind them without the Qiqirn Divers becoming afraid and running away. They have long but very narrow line of sight detection, which makes it possible to slip through just to the side.
The Giant Orobons ignore the PCs, and PCs cannot attack or use abilities on them.
The Giant Orobons run at enhanced speed probably as fast as a raptor's and will chase any Qiqirn it "aggroes".
Even if it is chasing a particular Qiqirn it has "aggroed", it will still "aggro" other Qiqirns it sees along the way. This is unlike usual party mechanics where the mob aggroes only its initial target.
When seen, the Qiqirn Divers will run to certain designated hiding spots on the map. The hiding spot they choose depends on the direction they run upon aggro. Typically, they will hide in tunnels or in hiding spots on ships, where Orobon don't roam or see them.
Qiqirn Divers have enhanced movement speed. Even while using Ninja Kyahan+1, being able to sufficiently catch up with them and stopping them with dialog is only possible by cutting corners and moving more efficiently than they could. Flee is very useful in catching up with them.
It takes 1 dialogue to stop it and 1 more dialogue to get it to follow you again.
Qiqirn tend to run in the opposite direction of an oncoming Orobon if trapped in a corridor. This can be used to your advantage if you are nearly trapped between two encroaching Orobon. Running intentionally into the Orobon coming up the rear can make the Qiqirn(s) run towards the end-point instead of away.
Talk to the Qiqirn Chief Diver at the end and he will give a message of either there being more Qiqirn to escort or if you have brought everyone.
A small island located at I-7, which is not included on the "safest route", is actually much easier to pass through. The normal route commonly has 2 or 3 Giant Orobon in the way while the island has at most 1 which can be avoided by standing behind the rock located there. Once you pass the island you are a straight shot to the finish line.